MicroRNAs as Biomarkers for Obstructive Sleep Apnea

Inclusion Criteria for Cases:

* age 18-75 years
* moderate-severe OSA (defined as AHI ≥15 events/hour)
* willing to accept PAP therapy

Inclusion Criteria for Controls:

* age 18-75 years
* no OSA (defined as AHI \<5 events/hour)

Exclusion Criteria for Cases:

* current use of PAP or other OSA treatments
* home oxygen therapy
* recent changes (within 3 months) to BP medications among those who are on these medications
* presence of Cheyne-Stokes Respiration (CSR) in sleep study
* predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events)
* pregnancy
* clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
* organ transplantation
* self-reported sleep duration less than 5 hours per night on weeknights (work nights)
* current night shift work

Exclusion Criteria for Controls:

* home oxygen therapy
* pregnancy
* clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
* organ transplantation
* self-reported sleep duration less than 5 hours per night on weeknights (work nights)
* current night shift work