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Prophylactic Antibiotics in Cystectomy With Diversion

Prophylactic Antibiotics in Radical Cystectomy With Urinary Diversion

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Presence of muscle invasive bladder cancer and planning to undergo radical cystectomy with either ileal conduit or neobladder diversion.
* 18 years of age or older

Exclusion Criteria:

* Currently receiving antimicrobials for active infection
* Poor renal function with GFR \< 30 ml/min
* Allergy to nitrofurantoin and unable to take an alternative antibiotic (cephalexin, trimethoprim-sulfamethoxazole, or ciprofloxacin)
* Pregnancy
* Unable to provide Informed consent
* Prior pelvic radiation

About the study

Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of postoperative urinary tract infections within the 90-day postoperative period in patients with muscle invasive bladder cancer who undergo radical cystectomy with urinary diversion.

What is being tested

• Prophylactic antibiotics postoperatively. (drug)

Sponsor: University of Minnesota · Participants: 120 · Started: May 13, 2024

Contact the study team

• Judith Graziano · Phone: 612-625-7486

Official record on ClinicalTrials.gov — NCT06190197

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.