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Improving Status Epilepticus Treatment Times

Quality Improvement in Time to Treatment of Status Epilepticus

Who can join

30 Days – 18 Years · All sexes

Inclusion Criteria:

* SE episode occurs in a male or female child aged between \> 30 days to \< 19 years
* Seizures meeting AT LEAST ONE of the following criteria:

  1. continuous clinically apparent seizure lasting greater than 5 minutes
  2. continuous clinically apparent seizure of any duration receiving BZD
  3. repeated seizures without return to neurological baseline within 5 minutes

Exclusion Criteria:

* SE episode occurs in a child with infantile spasms
* SE episode occurs in a child with electrographic-only seizures without clinical signs other than encephalopathy

About the study

This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children. The primary study endpoint is to decrease the time from the SE diagnosis to treatment with the first dose of a benzodiazepine (BZD) as measured during hospitalization, which will decrease chances of morbidity and mortality.

What is being tested

• Quality improvement bundle (other)
• Quality improvement bundle and local PDSA cycles with central support (other)
• Quality improvement bundle and local PDSA cycles without central support (other)

Sponsor: Nationwide Children's Hospital · Participants: 450 · Started: Feb 1, 2024

Contact the study team

• Adam Ostendorf, MD · Phone: 614-722-5145

Official record on ClinicalTrials.gov — NCT06194747

Locations in the U.S.

Conditions

• Status Epilepticus

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.