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Speech Pattern Evaluation and Analysis for Knowledge of AD

Connected Language and Speech Along the Spectrum of ADRD: Digital Assessment and Monitoring

Who can join

Ages 40 to 80 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Must be enrolled in the Wisconsin Alzheimer's Disease Research Center (W-ADRC) Clinical Core or IMPACT studies, or in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
* Cognitively unimpaired or have a diagnosis of Mild Cognitive Impairment (MCI)
* Ages 40-80 years
* Completion of a W-ADRC or WRAP study visit within the past or upcoming 12 months
* Have provided W-ADRC or WRAP with blood plasma Alzheimer's Disease

Exclusion Criteria:

* Not actively enrolled in W-ADRC or WRAP
* Diagnosis of dementia
* Impaired capacity or unwilling to consent
* Major neurological conditions
* Speech disorders

About the study

The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD). This study aims to clarify how speech may be affected by Alzheimer's disease.

Participants will complete speech collection sessions and a survey at home using an iPad. Participants can expect to be in the study for 3 years.

What is being tested

• TalkTracker (other)

Sponsor: University of Wisconsin, Madison · Participants: 165 · Started: Jan 22, 2025

Contact the study team

• Lizzy Sielaff · Phone: 608-264-1019

Official record on ClinicalTrials.gov — NCT06230783

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.