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Enriched Holistic Care to Eradicate Disparities in Maternal Morbidity

The ENHANCED Trial: Enriched Holistic Care to Eradicate Disparities in Maternal Morbidity

Who can join

Ages 16 to 55 · Women · Healthy volunteers welcome

Inclusion Criteria:

* Pregnant patients who self-identify as Black, Indigenous, Asian, or Latina (BIPOC)
* Ages 16-55
* Presentation to the hospital in pregnancy - this includes prenatal care or the emergency department
* Plan to deliver at the 2 Penn hospital sites
* Patients must be able to read and understand English or Spanish
* Participants must be willing and able to sign the informed consent form

Exclusion Criteria:

* Unable to provide written consent by being unable to read or sign informed consent.
* Enrolled in ENHANCED Trial in a prior pregnancy
* Already participating in Maternity Care Home Model (MCHM)

About the study

The goal of this randomized controlled intervention trial is to evaluate an integrated, interdisciplinary, multi-level maternity care home model (MCHM) aimed at reducing severe maternal morbidity (SMM) among a group of Black indigenous and people of color (BIPOC) patients.

The main question it aims to answer is whether a patient-centered MCHM will address the gap in social, structural, and health system factors that contribute to disparities for the most vulnerable patients, thereby reducing SMM.

Participants will be randomized to a MCHM (office-based prenatal care that is integrated with social services within the MCHM) or standard of care (office-based prenatal care with individually outsourced social services referrals) and followed during pregnancy through 1 year postpartum.

What is being tested

• Maternity care home model (MCHM) (other)

Sponsor: University of Pennsylvania · Participants: 2,300 · Started: Jan 30, 2024

Contact the study team

• Sindhu K Srinivas, MD, MSCE · Phone: 215-662-2982
• Elizabeth Norton, MPH, MBE · Phone: 215-349-5277

Official record on ClinicalTrials.gov — NCT06245057

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.