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Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff

Who can join

Ages 21 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans/week will be considered for this project
* Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans/week.
* Age 21 years or older
* Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification
* Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits
* Willing to abstain from nicotine and tobacco products 12-hours before study visit
* Ability to read and speak English

Exclusion Criteria:

* Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit)
* Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
* History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months
* Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months
* Severe periodontal or oral lesions

About the study

This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco \[SLT\]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.

What is being tested

• Biospecimen Collection (procedure)
• Carbon Monoxide Measurement (procedure)
• Smokeless Tobacco Use (behavioral)
• Survey Administration (other)

Sponsor: Ohio State University Comprehensive Cancer Center · Participants: 80 · Started: Dec 20, 2024

Contact the study team

• The Ohio State Comprehensive Cancer Center · Phone: 800-293-5066

Official record on ClinicalTrials.gov — NCT06249984

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.