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Gut Microbiome Studies in Patients With POEMS Syndrome and Other Plasma Cell Disorders

RecruitingObservational studyHealthy volunteers welcome

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Diagnosed with POEMS syndrome (newly diagnosed or in remission) or with newly diagnosed multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), amyloid light chain (AL) amyloidosis or healthy controls from their households

Exclusion Criteria:

* Age under 18 years
* Pregnancy
* Substance abuse
* Antibiotics use or gastrointestinal endoscopy in the 3 months prior to the study participation
* Chronic gastrointestinal disorder
* Gastrointestinal surgeries in the past 2 years
* Chemotherapy (including anti-plasma cell treatment and steroids) or radiation treatment for cancer within the last 2 years or active cancer (other than plasma cell disorder)

About the study

A Study to Evaluate Gut Microbiome with POEMS Syndrome and Other Plasma Cell Disorders

What is being tested

Sponsor: Mayo Clinic · Participants: 240 · Started: Dec 29, 2021

Contact the study team

Official record on ClinicalTrials.gov — NCT06252948

Locations in the U.S.

MinnesotaMayo Clinic in Rochester, Rochester

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.