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Alcohol After Bariatric Surgery 2

Pharmacokinetics and Responses to Alcohol After Bariatric Surgery

Who can join

Ages 21 to 64 · All sexes

Inclusion Criteria:

* Surgery groups:

  * Male and female, 21-64 yrs. of age
  * Drink at least 1 standard drink per month but no more than 7 per week (women or \> 14 for men)
  * Underwent SG surgery 1-5 years ago

Non-surgery control group

* Male and female who did not undergo bariatric surgery
* Age , BMI, race , and alcohol pattern of consumption equivalent to participants in the SG surgery groups

Exclusion Criteria:

* For all groups (surgery and non-surgery groups)

  * Smoking or having quit smoking less than 2 months ago
  * Pregnant or breastfeeding
  * Taking any medications that might affect alcohol metabolism
  * Anemia
  * Gastritis, colitis, Crohn's Disease, malabsorptive diseases, inflammatory diseases, liver disease, kidney disease, cancer less than five years ago, stroke, or severe organ dysfunction
  * Body weight \>450 pounds (because of a limit on body composition machine)
  * Alcohol use disorder
  * Regular use of drugs with addiction potential or regular misuse of substances
  * Abnormality on EKG as determined by a study physician to present a safety risk

About the study

The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\[s\]it aims to answer are:

* Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy? * What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy?

Participants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal.

Researchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.

What is being tested

• Alcohol (Ethanol) (drug)

Sponsor: University of Illinois at Urbana-Champaign · Participants: 88 · Started: Jul 31, 2024

Contact the study team

• Rafael Guimaraes de Lima, PhD · Phone: 217-300-2374
• Rafael Guimaraes de Lima, PhD · Phone: 217-300-4709

Official record on ClinicalTrials.gov — NCT06257771

Locations in the U.S.

Conditions

• Hypoglycemia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.