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Ketamine as a Supplement to Local Anesthesia for Minor Procedures
Intranasal Ketamine as a Supplement to Local Anesthesia to Reduce Pain Associated With Minor Procedures in the Emergency Department
Who can join
Ages 7 to 70 · All sexes
Full eligibility criteria
Inclusion Criteria: * Undergoing Minor Procedure in the ED * Weight not to exceed 115kg Exclusion Criteria: * Altered Mental Status * Pregnancy * Breastfeeding * Acute head or eye injury * Intercranial Hypertension * Hx of seizures * Hx of chronic pain * Unstable vital signs * Allergy to Ketamine * Hepatic or Renal Insufficiency * Hx of Psychiatric Illness * Hx of alcohol/drug abuse
About the study
This trial is a double-blind randomized controlled clinical trial of adults and children (ages 7 to less than 70 years). Patients who present to the ED and who undergo minor bedside procedures that require local anesthesia will be divided into two groups: The first group will be treated with 0.7 mg/kg intranasal ketamine as well as standard local anesthesia for the procedure (treatment cohort). The second group will be treated with a volume-based dose of intranasal saline solution as well as standard local anesthesia for the procedure (control cohort). The primary aim is to assess whether patients in the treatment cohort report lower pain scores on the Numerical Rating Scale (NRS-100) when compared to patients in the control cohort. For adult patients, a secondary aim is to compare agitation between the two cohorts using the Richmond Agitation Sedation Scale (RASS) and, for pediatric patients, a secondary aim is to compare alertness between the two cohorts using the University of Michigan Sedation Scale (UMSS).
Results obtained from specific procedures will be analyzed on a spectrum of complexity and general length of recovery time. Scientific achievements may include finding a safe and effective way to reduce pain and discomfort during minor procedures in the Emergency Department. Additionally, it would provide opportunities for more research on sub-dissociative doses of ketamine during minor procedures: a topic in which there is still a gap in the published research
What is being tested
- Ketamine (drug)
- Saline (other)
Sponsor: Loyola University · Participants: 108 · Started: May 25, 2022
Contact the study team
- Shannon Lovett, MD · Phone: 708-327-2549
- Trent Reed, DO · Phone: 708-216-4117
Official record on ClinicalTrials.gov — NCT06284473
Locations in the U.S.
| Illinois | Loyola University Medical Center, Maywood |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.