Vasodilator and Exercise Study for DMD (VASO-REx)

Inclusion Criteria:

* Diagnosis of DMD confirmed by genetic report
* Minimum entry age of 6.0 years old
* Ambulatory
* On stable glucocorticoid regimen (for \> 3 months)

Exclusion Criteria:

* Contraindication to a Magnetic resonance Imaging examination (e.g. severe claustrophobia, magnetic implants, unable/unwilling to perform test)
* Presence of unstable medical problems, including severe cardiomyopathy, left ventricular ejection fraction \<45%, cardiac conduction abnormalities as evidenced on ECG, uncontrolled seizure disorder, uncontrolled hypo or hypertension
* Presence of a secondary condition that impacts muscle function or muscle metabolism (e.g., myasthenia gravis, endocrine disorder, mitochondrial disease)
* Presence of a secondary condition leading to developmental delay or impaired motor control (e.g., cerebral palsy) or previous history of unprovoked rhabdomyolysis
* Contraindications to phosphodiesterase 5 inhibitors (use of nitrates, alpha-adrenergic blockers, other phosphodiesterase 5 inhibitors) or other medications known to modulate blood flow or muscle metabolism
* Participation in currently approved FDA trials or other investigational clinical trials during the period of the study