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Evaluation of Free Gingival Graft Timing

RecruitingHealthy volunteers welcome

Evaluation of Free Gingival Graft Timing in Staged Guided Bone Regeneration: A Randomized Controlled Trial

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* • At least 18 years old

  * No uncontrolled medical conditions or medications that will affect their bone healing.
  * Good oral hygiene is defined as a full-mouth plaque score ≤25%11.
  * Must be able to read and understand the informed consent document.
  * Has a need for implants to replace missing tooth/teeth in at least 1 quadrant of the mouth.
  * Insufficient alveolar ridge width for endosseous implant placement, defined as 5 mm or less, as determined by bone sounding and CBCT scan.
  * The patient and/or guardian is willing and able to comply with pre-operative and post-operative diagnostic and clinical evaluations required.
  * The patient is not pregnant or breastfeeding.

Exclusion Criteria:

* Active infectious diseases.

  * Liver or kidney dysfunction/failure.
  * Uncontrolled diabetes (HbA1c ≥ 8.5).
  * Active cancer treatment - such as active chemotherapy radiation therapy, or radiotherapy performed within ≤12 months from the procedure.
  * Taking medications that will affect their bone healing (for example, bisphosphonates and long-term anti-inflammatory medications).
  * Metabolic bone diseases that affect bone healing such as osteoporosis.
  * Pregnant or lactating women (self-reported).
  * Current tobacco and Marijuana smokers have 10 or more cigarettes per day, and former smokers (\> 10 cigarettes) who quit \< 10 ago (self-reported).
  * Poor oral hygiene.
  * Vertical loss of bone at the edentulous ridge.
  * History of periodontal disease.
  * The patient is pregnant or breastfeeding

About the study

This clinical trial aims to compare and evaluate the clinical outcomes between two distinct treatment sequences: free gingival graft surgery preceding guided bone regeneration and guided bone regeneration followed by free gingival graft.

What is being tested

Sponsor: University of Alabama at Birmingham · Participants: 30 · Started: Aug 12, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06294587

Locations in the U.S.

AlabamaUnversity of Alabama at Birmingham, School of Dentistry, Birmingham

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.