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A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser
RecruitingHealthy volunteers welcome
A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a Difference Frequency Generation (DFG) Laser and Carbon Dioxide (CO2) Laser
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Subjects must be able and willing to provide written informed consent and comply with the requirements of the study protocol; * Subjects must be in good general health, based on answers provided during the screening visit; * Subjects must be able to read and understand English. * Subjects must be above the age of 18. * Subjects must have no history of skin conditions that affect the integrity of the skin barrier. Exclusion Criteria: * Are pregnant or lactating; * Have a history of drug or alcohol abuse or have reported habitual alcohol intake greater than 2 standard drinks per day \[e.g., 2 beers, 2 glasses of wine, or 2 mixed drinks\]; * Are smoking or have a history of smoking; * Presence of eczema, psoriasis, skin wounds or ulcers, or any other skin disease on the thighs; * Have birth marks, tattoos, scars, or any other disfiguration of the skin in the skin area of interest; * Presence of sunburn or tan in the treatment area; * Use of any topical application of retinoids in the area of interest or systemic retinoids in the past 6 months; * Use of any prescription topical medication, such as corticosteroids or hydroquinone on the skin area of interest in the past 6 months; * History of blood-clotting abnormality; * History of keloid formation or hypertrophic scarring; * History of allergic reaction to local anesthesia, aluminum chloride, and/or glycerol; * Investigator, interfere with study evaluations or pose a risk to subject safety during the study; * Exhibits any clinical conditions or takes any medication which in the opinion of the investigator may interfere with the study or pose a risk to subject safety during the study; * Is not able to follow study protocol.
About the study
This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime.
What is being tested
- DFG Laser (device)
- CO2 Laser (device)
- Optical coherence tomography (OCT) (device)
Sponsor: Massachusetts General Hospital · Participants: 23 · Started: Oct 16, 2024
Contact the study team
- Alicia Van Cott, NP · Phone: 617-726-4454
- Amelia Carlson, BS · Phone: 617-726-4454
Official record on ClinicalTrials.gov — NCT06295471
Locations in the U.S.
| Massachusetts | MGH Clinical Unit for Research Trials & Outcomes in Skin, Boston |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.