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Biomarkers for Peripheral Circadian Clocks in Humans

Who can join

Ages 17 to 35 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1\) 17-35 years old 2) English speaking 3) Healthy 5) Altitude history: Currently residing at Denver altitude or higher

Exclusion Criteria:

1\. Any medical, psychiatric, or sleep disorder.

About the study

The purpose of this project is to improve our understanding of peripheral circadian rhythms in humans. Circadian clocks are present in most tissues of the body with importance for optimal physiological function, health, and behavior. This project will utilize simulated jetlag protocols to systematically test novel hypotheses about the regulation of peripheral circadian rhythms in humans. Specifically, we will examine how changes in the time of when we are exposed to light and the timing of when we eat impacts proteins in the blood and saliva that represent rhythms from clocks in the brain (e.g., rhythms of the hormones melatonin and cortisol coordinated by the brain) and rhythms from clocks in body tissues (e.g., proteins made by immune and bone cells, and cells in the stomach and liver). We also aim to discover new blood-based biomarkers of peripheral rhythms in humans. We anticipate our findings will be the first step in developing novel circadian based treatments for aligning peripheral clocks under conditions such as jetlag, and for developing novel circadian biomarkers that will advance our scientific understanding of circadian rhythms.

What is being tested

• Simulated jetlag protocol (behavioral)

Sponsor: University of Colorado, Boulder · Participants: 14 · Started: Sep 1, 2023

Contact the study team

• Kenneth Wright, PhD · Phone: 303-735-1923

Official record on ClinicalTrials.gov — NCT06296823

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.