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Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)

RecruitingHealthy volunteers welcome

Who can join

Ages 18 to 59 · Women · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Women aged 18-59
* Heterogeneously dense/extremely dense (BIRADS 3 or 4) breast tissue on mammogram within the past 12 months
* Physically inactive; engaging in \<60 minutes of moderate or vigorous intensity exercise per week, as assessed by Godin Leisure Time screener
* Not pregnant or breastfeeding
* English speaking and able to read English. Investigators are only enrolling English-speaking participants to this study at this time due to the fact that investigators currently only have English-speaking exercise trainers with the proper qualifications to conduct the exercise training
* Written informed consent prior to any study-related procedures

Exclusion Criteria:

* Self-reported inability to walk 2 blocks (at any pace)
* Prior history of breast cancer; prior DCIS is allowable as long as participant is not taking endocrine therapy and has at least 1 breast that has not been irradiated
* On oral or implantable hormonal contraceptives, postmenopausal hormone replacement therapy, a selective estrogen receptor modulator or an aromatase inhibitor; Mirena or other IUD is acceptable
* Consistent strength training in the past 3 months
* Use of weightloss drugs
* Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate exercise. Examples would include unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and osteoarthritis requiring imminent joint replacement. Moderate arthritis that does not preclude physical activity is not a reason for ineligibility
* Psychiatric disorders or conditions that would preclude participation in the study intervention (e.g. untreated major depression or psychosis, substance abuse, severe personality disorder)

About the study

The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating in an exercise program.

The names of the study groups in this study are:

* Exercise Training Group * Waitlist Control Group

What is being tested

Sponsor: Dana-Farber Cancer Institute · Participants: 46 · Started: Mar 28, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06322888

Locations in the U.S.

MassachusettsDana Farber Cancer Institute, Boston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.