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MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence

MedSupport: A Novel Multilevel Intervention to Identify and Address Barriers to Pediatric Medication Adherence

Who can join

All ages · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Parent of a child diagnosed with acute lymphoblastic leukemia (ALL)
* Child patient age 365 days to \< 19 years at time of study entry.
* Parent's child patient's therapy must include 6-mercaptopurine (6-MP) administered orally or by nasogastric (NG) tube.
* Verbal fluency in English, or Spanish
* Parent has a smartphone or computer access with an Internet connection.
* Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure.

Exclusion Criteria:

* Parent is unwilling or unable to follow protocol requirements.

About the study

This clinical trial identifies and addresses barriers to pediatric medication adherence among families of children with acute lymphoblastic leukemia. Pediatric nonadherence (noncompliance) to medication is a significant public health problem, and rigorous research repeatedly documents that nonadherence increases risk for hospitalization, healthcare cost, disease progression, and death. Pediatric acute lymphoblastic leukemia (ALL) patients who miss 5% of 6-mercaptopurine (6-MP) doses within the 2-year 6-MP regimen have a 2.7-fold risk of cancer that comes back after a period of improvement (relapse). To address these families' needs, researchers have developed MedSupport, a theory-based multilevel intervention with targets at the organizational, healthcare team, and caregiver levels that is designed to address root barriers to medication adherence. This study is being done to better understand families' experiences giving their child oral chemotherapy at home and to help families cope with the day-to-day challenges of giving their child medication.

What is being tested

• Best Practice (other)
• Biospecimen Collection (procedure)
• Electronic Health Record Review (other)
• Interview (other)
• Medical Device Usage and Evaluation (other)
• Medical Device Usage and Evaluation (other)

Sponsor: Roswell Park Cancer Institute · Participants: 150 · Started: Feb 11, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06323044

Locations in the U.S.

Conditions

• Acute Lymphoblastic Leukemia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.