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Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

A Prospective Clinical Trial of Radiation Therapy for Dupuytren's Contracture Following Surgical and Non-Surgical Release

Who can join

Ages 45 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 45 or greater with DC
* Extension deficit \>10 degrees
* Unable to simultaneously place the affected finger and palm flat on a table.
* Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
* For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included

Exclusion Criteria:

* Unsuccessful non-surgical release (\> N/1 disease)
* They develop an open wound during CCH
* Breast feeding or pregnancy
* A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
* Less than the age of 45
* They have previously undergone radiation on the hand in which they plan to get CCH injections
* They are pregnant women, impaired adults or prisoners

About the study

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are:

• Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum?

Participants will undergo:

* Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

What is being tested

• Radiation therapy (radiation)

Sponsor: Dartmouth-Hitchcock Medical Center · Participants: 95 · Started: Sep 16, 2024

Contact the study team

• Peter A DePalo, BS, CCRP · Phone: 603 653-0494
• Lance Warhold, MD · Phone: 603 650-5133

Official record on ClinicalTrials.gov — NCT06330545

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.