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Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome

Intraoperative Brief Electrical Stimulation to Improve Cross-Face Nerve Grafting Outcomes

Who can join

Ages 18 to 80 · All sexes

Inclusion Criteria:

1. Patients 18-80 years-old with unilateral facial paralysis who are candidates for two- stage CFNG smile reanimation surgery (i.e. CFNG-driven free gracilis muscle transfer (FGMT) or dual innervation FGMT).
2. Agree to participate in the study.

Exclusion Criteria:

1. Bilateral facial paralysis
2. Age less than 18 years-old or older than 80 years-old
3. Comorbid medical condition preventing two-stage CFNG surgery

About the study

A research study to find out if brief intraoperative electrical stimulation therapy improves nerve regeneration and smile outcomes following two-stage cross face nerve graft facial reanimation surgery.

What is being tested

• BES (procedure)
• Standard of Care surgery (procedure)

Sponsor: The Cleveland Clinic · Participants: 20 · Started: Mar 1, 2023

Contact the study team

• Hana Rosen, MD · Phone: 216-444-7018
• John O'Neill, MD · Phone: 440-445-8175

Official record on ClinicalTrials.gov — NCT06335719

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.