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Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology

RecruitingPhase 2

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Diagnosis of cancer
* Age 18 or older.
* Admitted to a medical floor.
* Dyspnea intensity at rest of at least 4 on a 0-10-point NRS (where 0 = none, 10 = worst).
* Speak English or Spanish.

Exclusion Criteria:

* Hemodynamic instability requiring active Merit Team or ICU team involvement.
* Delirium as per clinical team's assessment in the Electronic Health Record (EHR).
* Severe hypoxemia (SpO2 \< 90% despite supplemental oxygen of up to 6 L/min).
* Continuous positive airway pressure (CPAP) use for obstructive sleep apnea, actively using \>10 hours a day.
* Respiratory failure necessitating mechanical ventilation (i.e., HFNC or NIV), and planned thoracentesis within 72 hours of enrollment.
* Patients with known pregnancy.

About the study

To learn about the effect of Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology (SPOT-ON) treatment on the severity of shortness of breath in patients with cancer.

What is being tested

Sponsor: M.D. Anderson Cancer Center · Participants: 150 · Started: Jun 11, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06336642

Locations in the U.S.

TexasMD Anderson Cancer Center, Houston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.