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Health Effects of Grain Foods in Adults

Who can join

Ages 21 to 60 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* male and female; 21 to 60 years old; Hemoglobin A1c concentration between 5.7 and 6.4%
* Prefer no use of medications, but if on medication, must have been on a stable dose for 3 months and plan to remain at the same dose for the duration of the trial.
* low customary intake of whole grain foods (less than 2 servings per day) and high energy from added sugar (greater than 10% energy).

Exclusion Criteria:

* Grain or dairy sensitivities or allergies or celiac disease; sensitivity or allergy to other foods that would result in refusal to eat a class of foods.
* smoker
* intended weight loss or gain during the study period; intended change of activity level during the study period
* use of blood thinners
* prior gastrointestinal surgery.

About the study

This study will assess the effects of eating whole grain foods versus refined grain foods with different amounts of added sugar. It is hypothesized that a diet including grain products will have beneficial effects on taste hedonics, appetite, food/energy intake, body weight, blood pressure, acute and chronic glycemia and acute and chronic lipemia compared to customary diets controlling for added sugars, saturated fats and sodium.

What is being tested

• High Whole Grain, Low Sugar (other)
• Low Whole Grain, Low Sugar (other)
• High Whole Grain, High Sugar (other)
• Low Whole Grain, High Sugar (other)

Sponsor: Purdue University · Participants: 120 · Started: Jan 18, 2024

Contact the study team

• Judy George, BS · Phone: 4654946192
• Richard Mattes, PhD · Phone: 7654940662

Official record on ClinicalTrials.gov — NCT06339879

Locations in the U.S.

Conditions

• Hyperlipidemias

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.