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Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury: Randomized Controlled Trial
Who can join
Ages 18 to 85 · All sexes
Full eligibility criteria
Inclusion Criteria: * Able to provide informed consent * Scheduled for elective cardiac surgery with cardiopulmonary bypass Exclusion Criteria * Emergency procedures * Scheduled for heart or lung transplantation * Scheduled for ventricular assist device implantation * Use of the Medtronic Elongated Once-Piece Arterial Cannula * Diagnosed with sepsis * Diagnosed with delirium * Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90) * Requiring mechanical circulatory support * Requiring vasoactive medications
About the study
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.
What is being tested
- Non-pulsatile blood flow (other)
- Pulsatile blood flow (other)
Sponsor: University of Colorado, Denver · Participants: 1,100 · Started: May 19, 2025
Contact the study team
- Nathan J Clendenen, MD,MS · Phone: 3037245000
Official record on ClinicalTrials.gov — NCT06349577
Locations in the U.S.
| Colorado | University of Colorado Hospital, Aurora |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.