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Biomarkers to Predict Cancer Therapy-related Cardiotoxicity

RecruitingObservational study

Biomarkers to Predict Cancer Therapy-Related Cardiotoxicity

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* 18 years of age or older
* Treated for any malignancy with any type of chemotherapy including oral, parenteral therapy and immunotherapy
* One of the following:

  * Diagnosed with cardiotoxicity defined as; cardiomyopathy, symptomatic heart failure, asymptomatic reduced systolic function, acute coronary syndrome, myocardial infarction, critical limb ischemia, cardiac arrhythmias or myocarditis possibly related to prior cancer treatment
  * Completed chemotherapy with no cardiotoxicity at least two years post treatment
  * Patients with cancer who will be initiating systemic therapy with potentially cardiotoxic medications. This will include chemotherapy, immunotherapy, targeted therapy that have been associated with cardiac toxicity
* An understanding of the protocol and its requirements, risks, and discomforts
* The ability and willingness to sign an informed consent

Exclusion Criteria:

\- Inability on the part of the patient to understand the informed consent or be compliant with the protocol

About the study

This study evaluates why some cancer patients but not others experience changes in heart function following treatment with chemotherapy.

What is being tested

Sponsor: Mayo Clinic · Participants: 693 · Started: May 3, 2019

Contact the study team

Official record on ClinicalTrials.gov — NCT06353191

Locations in the U.S.

ArizonaMayo Clinic in Arizona, Scottsdale
FloridaMayo Clinic in Florida, Jacksonville
Moffitt Cancer Center, Tampa

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.