Home › NCT06355895

Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies

The Effect of Liver Volume Variation on Stereotactic Body Radiation Therapy (SBRT) Planning and Delivery for Upper Abdominal Malignancies

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

• Have primary upper abdominal (pancreatic, bile duct, liver) cancer or upper abdominal metastases (liver, adrenal, upper abdominal lymph nodes) planned to undergo SBRT.

Exclusion Criteria:

* Had prior Radiation Therapy to the liver
* Contraindication to receipt of iodinated IV contrast for CT (such as renal insufficiency or allergy that cannot be overcome by premedication)
* Pregnancy/lactation OR woman of childbearing potential who is unable or unwilling to use adequate contraception during Radiation Therapy.
* Inability to fast.

About the study

Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fasting/fed variations in liver volume therefore carry substantial potential for introducing errors into estimates of dose-volume distribution within normal liver tissue, as well as affecting day-to-day setup fidelity and organ alignment for treatment. This prospective study will examine how diurnal and fast-fed variations in liver volume affect treatment planning for abdominal SBRT.

What is being tested

• Standardized high-carbohydrate meal (dietary supplement)

Sponsor: University of Pittsburgh · Participants: 17 · Started: May 16, 2024

Contact the study team

• Samantha Demko, BSN · Phone: 412-623-1400
• Brieanna Marino, MS · Phone: 412-647-8258

Official record on ClinicalTrials.gov — NCT06355895

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.