Home › Surgical Wound Infection › NCT06363877

Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Wound Irrigation and Peritoneal Lavage With Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Who can join

Ages 18 to 80 · All sexes

Inclusion Criteria:

* 18 to 80 years of age
* undergoing an exploratory laparotomy for Centers for Disease Control class II and III wounds

Exclusion Criteria:

* Pregnancy
* Preoperative abdominal wall skin/soft tissue infection
* Iodine allergy
* Patients unlikely to survive beyond 30 days
* Patients with mesh placement or placement of a foreign body except for drains

About the study

This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.

What is being tested

• Povidone-Iodine (drug)
• Normal Saline (drug)

Sponsor: Loma Linda University · Participants: 1,100 · Started: Jun 3, 2024

Contact the study team

• Martin G Rosenthal, MD · Phone: 909-558-4000

Official record on ClinicalTrials.gov — NCT06363877

Locations in the U.S.

Conditions

• Surgical Wound Infection

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.