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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

RecruitingObservational study

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes: PROMISE-Lung Study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

1. Able to understand and provide informed consent
2. ≥ 18 years of age at the time of written informed consent
3. Anticipated listing or listed for a single or bilateral cadaveric donor lung transplant or having received a lung transplant within 30 days

   * Participants undergoing repeat lung transplantation or multi-organ transplantation are eligible if they meet the inclusion/exclusion criteria.

Exclusion Criteria:

1. Unwillingness of a participant or legally authorized representative (LAR) to give written informed consent or comply with study protocol
2. Pregnancy or plans to become pregnant
3. Past or current medical problems or findings from physical examination or laboratory testing, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

About the study

This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.

Sponsor: Duke University · Participants: 2,600 · Started: Sep 3, 2024

Contact the study team

Allyn Damman · Phone: 919-259-4414
Carl Schuler, RN · Phone: 919-695-2721

Official record on ClinicalTrials.gov — NCT06399302

Locations in the U.S.

California	University of California Los Angeles, Los Angeles University of California at San Francisco, San Francisco Stanford University Medical Center, Stanford
Florida	University of Miami, Miami
Maryland	Johns Hopkins University, Baltimore
Massachusetts	Brigham and Womens Hospital, Boston
Michigan	University of Michigan, Ann Arbor
Minnesota	University of Minnesota, Minneapolis
New York	Columbia University, New York New York University, New York
North Carolina	Duke University Medical Center, Durham
Pennsylvania	University of Pennsylvania, Philadelphia University of Pittsburgh Medical Center, Pittsburgh
Tennessee	Vanderbilt University Medical Center, Nashville
Texas	Houston Methodist Hospital, Texas Medical Center, Houston
Virginia	Inova Fairfax Hospital, Falls Church
Washington	University of Washington, Seattle
Wisconsin	University of Wisconsin Hospital and Clinics, Madison

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.