Facilitating Neuroplastic Changes of Acute Stroke Survivors
RecruitingPhase 1/2
Facilitating Neuroplastic Changes of Acute Stroke Survivors With Severe Hemiplegia
Who can join
Ages 30 to 85 · All sexes
Full eligibility criteria
Inclusion Criteria: * Acute first time unilateral hemispheric stroke (hemorrhagic or ischemic stroke, 24 hours after admission to 1 month post-stroke at the start of the proposed treatment) * Hemiplegia or hemiparesis * 0≤Manual Muscle Testing (MMT)\<=2 * Age 30-85 * Ankle impairments including stiff calf muscles and/or inadequate dorsiflexion Exclusion Criteria: * Medically not stable * Associated acute medical illness that interferes with ability to training and exercise * No impairment or very mild ankle impairment of ankle * Severe cardiovascular problems that interfere with ability to perform moderate movement exercises * Cognitive impairment or aphasia with inability to follow instructions * Severe pain in legs * Severe ankle contracture greater than 15° plantar flexion (when pushing ankle to dorsiflexion) * Pressure ulcer, recent surgical incision or active skin disease with open wounds present below knee
About the study
This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-stroke including patients who are paralyzed with no motor output. The early acute stroke rehabilitation device will be evaluated in this clinical trial.
What is being tested
- Motor relearning training (device)
- Passive stretching (device)
- Gamed-based active movement training (device)
- Passive movement (device)
- Active movement training (device)
- Ankle torque and motion measurement (device)
Sponsor: University of Maryland, Baltimore · Participants: 68 · Started: Jun 1, 2025
Contact the study team
- Peiwen Fu, BS · Phone: 410 706-8625
Official record on ClinicalTrials.gov — NCT06404268
Locations in the U.S.
| Maryland | UMROI, Baltimore University of Maryland Baltimore, Baltimore |
| Texas | TIRR Memorial Hermann, Houston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.