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Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure

Point-of-Care Ultrasound to Detect Vocal Fold Motion Impairment on Pediatric Patients on Noninvasive Positive Pressure Ventilation

Who can join

1 Day – 18 Years · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 0 to 18 years
* Scheduled to receive a fiberoptic nasolaryngoscopy with the otolaryngology team to assess for vocal fold motion impairment
* Status post great vessel, esophageal, or tracheal surgery that could disrupt the recurrent laryngeal nerve

Exclusion Criteria:

* Tracheostomy in place
* Age \>18 years
* History of vocal cord paralysis/paresis
* Patients who cannot have their neck placed in a neutral or slightly extended position due to injury or ligament laxity

About the study

The goal of this prospective, observational study is to evaluate for the presence of vocal fold motion impairment (VFMI) in the children admitted to the pediatric intensive care unit on noninvasive positive pressure ventilation (NIV PPV). Participants will have two ultrasounds of their vocal folds performed, once while on NIV PPV and once after weaned off of the NIV PPV. This results of these scans will be reviewed against one another and against the gold standard, fiberoptic nasolaryngoscopy (FNL). The main question this study aims to answer is: Can POCUS be used to reliably detect VFMI while pediatric patients on supported with NIV PPV?

What is being tested

• Point-of-Care Ultrasound of the Airway (diagnostic test)

Sponsor: Nemours Children's Clinic · Participants: 50 · Started: Mar 30, 2024

Contact the study team

• April Slamowitz, MD · Phone: 718-470-3000
• Catherine Geller, MD · Phone: 718-470-3000

Official record on ClinicalTrials.gov — NCT06406725

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.