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Local Anesthesia for Facial Fractures

The Impact of Perioperative Nerve Block on Opioid Use After Craniomaxillofacial Trauma Surgery: A Randomized Controlled Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Adults age 18 and over
2. Isolated facial fracture to the mandible and/or midface undergoing surgical repair
3. No allergy to local anesthetic
4. Ability to read, write, and understand English

Exclusion Criteria:

1. Patients under the age of 18
2. Isolated nasal bone fracture
3. Polytrauma (I.e. injury pattern resulting in hospital admission for multiple bony fractures outside of the face)
4. Allergy to local anesthetic

About the study

The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics. Patients with operative facial fractures are randomized to receive either bupivacaine or saline injections prior to the anesthesia emergence.

What is being tested

• Bupivacaine/Epinephrine (drug)
• Saline (drug)

Sponsor: Washington University School of Medicine · Participants: 70 · Started: Apr 2, 2024

Contact the study team

• Amrita Hari-Raj, MD · Phone: 314-518-6410
• Sara Kukuljan · Phone: 314-362-7563

Official record on ClinicalTrials.gov — NCT06429501

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.