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Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder
RecruitingPhase 2
Mindfulness-based Neurofeedback to Augment Dialectical Behavior Therapy (DBT) for Adults With Borderline Personality Disorder (Aim 1)
Who can join
Ages 18 to 60 · All sexes
Full eligibility criteria
Inclusion criteria: * age 18-60, * be able to provide written informed consent, * meet criteria for BPD on semi-structured clinical interview, * able to plan to keep any prescribed medications and psychotherapy constant during the study * fluent in English. Exclusion criteria: * current DBT psychotherapy outside the study * lifetime primary psychotic disorder * manic episode in the last one year * developmental disorder (e.g. autism) * history of learning disorder * severe substance use disorder in the last 3 months * active suicidal ideation with intent or plan in the past 3 months * history of major medical or neurologic disorder * MRI contraindications, including pregnancy * poor performance on reading task (WRAT \> 11 errors) * newly prescribed medications in the past 8 weeks * daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics) * any scheduled daily benzodiazepines * change in psychotherapy type or frequency in the past 12 weeks. * At the discretion of the study PI Eligibility will be determined by study personnel.
About the study
The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).
What is being tested
- mindfulness-based Neurofeedback (behavioral)
- control Neurofeedback (other)
Sponsor: Yale University · Participants: 150 · Started: Mar 13, 2025
Contact the study team
- Sarah K Fineberg, MD PhD · Phone: 203-974-7265
Official record on ClinicalTrials.gov — NCT06446765
Locations in the U.S.
| Connecticut | Connecticut Mental Health Center, New Haven |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.