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Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
Hemodynamic Management Following Acute Traumatic Spinal Cord Injury: A Randomized, Controlled Trial
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Traumatic spinal cord injury Exclusion Criteria: * Patients with an injury from a trauma that penetrates the spinal cord (i.e., gunshot or knife wound resulting in cord transection) * Preexisting neurologic or spinal cord injury * Severe traumatic brain injury as measured by a best resuscitated Glasgow Coma Scale (GCS) score of \<8 at 24 hours following injury * Presence of traumatic injuries that preclude spine surgery within 24 hours of presentation * Concomitant injury/illness requiring targeted blood pressure management (e.g., injury to the aorta, aortic dissection, hemorrhagic stroke) * Preexisting history of neuromotor disorders (i.e., cerebral palsy, Parkinson disease, etc.) * Not expected to survive \>24h * Cord transection identified by radiologist and agreed upon by the spine surgery team * Injury below spinal cord level L1 * Prisoners * Pregnant women
About the study
The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.
What is being tested
- Mean arterial blood pressure (MAP) goal of ≥65 mmHg (other)
- Mean arterial blood pressure (MAP) goal of 85-90 mmHg (other)
- Spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg (other)
Sponsor: The University of Texas Health Science Center, Houston · Participants: 228 · Started: Jul 3, 2024
Contact the study team
- David Meyer, MD, MS, FACS · Phone: (713) 500-7244
- Erin Fox · Phone: (713) 500-6273
Official record on ClinicalTrials.gov — NCT06451133
Locations in the U.S.
| Texas | The University of Texas Health Science Center at Houston, Houston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.