Home › Postoperative Nausea and Vomiting › NCT06488001
Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
Who can join
Ages 18 to 79 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia. Exclusion Criteria: * Pregnant, * Patients with gastrointestinal disease requiring ongoing medical management. * Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy. * Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery. * Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis. * Known r suspected malignancy * Lactose intolerance
About the study
The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79.
Researchers will compare a placebo to the active medication.
Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.
What is being tested
- pantoprazole (drug)
- Placebo (drug)
Sponsor: United States Naval Medical Center, Portsmouth · Participants: 132 · Started: Aug 26, 2022
Contact the study team
- Casey Timmerman, DO · Phone: 757-953-7767
Official record on ClinicalTrials.gov — NCT06488001
Locations in the U.S.
| Virginia | Naval Medical Center Portsmouth, Portsmouth |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.