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Celecoxib for ENT Pain Management
Celecoxib Pain Management Following Superficial Parotidectomy: Opioid Sparing Protocol
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Ability to understand and the willingness to sign a written informed consent document * Willing to comply with all study procedures and be available for the duration of the study * Ability to take oral medication * Undergoing superficial parotidectomy * Individuals at least 18 years of age * Adequate organ function as indicated by standard laboratory tests: hematology (complete blood count), clinical chemistry Exclusion Criteria: * History of NSAIDs contraindication (severe congestive heart failure, CABG within 14 days, arrhythmias, significant coronary artery disease, cardiomyopathy, severe hepatic impairment, history of peptic ulcer disease or GI bleeding, use of anticoagulation (other than prophylactic aspirin) * History of uncontrolled hypertension, cerebrovascular accident, sulfa allergy, allergy to celecoxib * Concurrent use of CYP2C9 potentiator/inhibitor * Use of investigational drugs, biologics, or devices within 30 days prior to randomization. * Individuals who are pregnant, lactating or planning on becoming pregnant during the study. * Not suitable for study participation due to other reasons at the discretion of the investigators.
About the study
The goal of this clinical trial is to find out whether pain can be managed after an operation with celecoxib instead of oxycodone. The main question it aims to answer is if use of celecoxib plus Tylenol reduces the need for oxycodone.
Researchers will compare the combination of celecoxib and Tylenol to a placebo to find out whether celecoxib works to manage pain.
Participants will:
* Take celecoxib, or a placebo, plus Tylenol with opioids as needed * Keep a diary of their pain between visits * Complete questionnaires
What is being tested
- Celecoxib (drug)
- Tylenol (drug)
- Oxycodone (drug)
- placebo (drug)
Sponsor: University of Wisconsin, Madison · Participants: 84 · Started: Feb 28, 2025
Contact the study team
- Hayley Mann, MD · Phone: 480-272-4258
Official record on ClinicalTrials.gov — NCT06505187
Locations in the U.S.
| Wisconsin | University of Wisconsin, Madison |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.