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Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)

Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults

Who can join

Ages 60 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Male or female aged 60 or above
2. Free of chronic disease
3. No structured exercise program (2 or more bouts/wk) within previous 12 months
4. Cognitively capable of providing informed consent

Exclusion Criteria:

1. Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and/or testing bouts
2. Cardiopulmonary disorders or reduced breathing capacity
3. Metabolic diseases including markers of liver disease (ALT \> 52 U/l) and type 2 diabetes (HbA1C = or \> 6.5, fasting blood glucose = or \> 126 mg/dl)
4. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)
5. Any current infectious disease
6. Life expectancy \< 1 year
7. Insulin sensitizing/blood glucose lowering agents such as metformin or metabolic weight loss agents (e.g. GLP-1 agonists)
8. High dose statin (dose equivalent of 40 mg/d or higher simvastatin)
9. Lidocaine allergy
10. Regular tobacco use and/or vaping
11. Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/d or 14 drinks/wk for males)
12. BMI 35.0 kg/m2 or higher
13. Unable to commit to \~6 months required to complete the study

About the study

Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.

What is being tested

• Combined endurance and resistance training (other)

Sponsor: Florida Institute for Human and Machine Cognition · Participants: 250 · Started: Jan 27, 2025

Contact the study team

• Craig Tuggle · Phone: 205-352-6036

Official record on ClinicalTrials.gov — NCT06507189

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.