Home › NCT06512181

Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders

Who can join

Ages 18 and older · Women

Inclusion Criteria:

1. Provision of signed and dated informed consent form.
2. Stated willingness to comply with all study procedures and availability for the duration of the study.
3. A person with a uterus, age 18 or older
4. Currently pregnant with an intrauterine gestation or postpartum
5. Suspected of having PAS based on history, clinical findings, and/or imaging
6. Patients for whom the usual management would be peripartum hysterectomy.
7. Patient desires uterine preservation or declines hysterectomy
8. Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration.

Exclusion Criteria:

• Have a low antenatal suspicion for PAS based on imaging.

About the study

This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred by some patients. In selected participants (n=15) who desire uterine preservation, the investigators provide the option of conservative management, which will be defined as leaving the placenta in the uterus after delivery of the infant. This is a single-arm single-site pilot study where all participants will be carefully monitored during a standard postpartum inpatient stay and with outpatient follow-up until the uterus is empty.

What is being tested

• Conservative/Expectant Management (other)

Sponsor: University of Pennsylvania · Participants: 15 · Started: Apr 21, 2025

Contact the study team

• Beth Pineles, MD Phd · Phone: 267-226-7933

Official record on ClinicalTrials.gov — NCT06512181

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.