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Ketorolac Effects on Post-operative Pain and Lumbar Fusion

Ketorolac Effects on Post-operative Pain and Lumbar Fusion: a Double Blind Randomized Controlled Trial

Who can join

Ages 18 to 85 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 18-85 years old (inclusive)
* Elective posterior lumbar instrumented fusion
* One or two level fusion
* Consent to participate in study and willing to adhere to study follow up
* English proficiency

Exclusion Criteria:

* \< 18 or \> 85 years old
* History of renal failure, dialysis, or creatinine over 1.50 mg/dl
* Active or recent smoker (active within past 6 months)
* Revision surgery
* Auto/worker compensation
* Active cancer or history of chemotherapy in past 6 months
* Active narcotic use within 3 months of surgery date
* Infection at operative levels
* Any allergies to NSAIDs or Opioids

About the study

A double blind prospective randomized trial of IV ketorolac vs. placebo in management of patients undergoing lumbar one or two level spinal fusions.

What is being tested

• Ketorolac Tromethamine (drug)
• Placebo (drug)

Sponsor: University of Maryland St. Joseph Medical Center · Participants: 140 · Started: 2026-01

Contact the study team

• Aja Janyavula · Phone: 410-427-5459
• Sam Rudow · Phone: 410-427-5459

Official record on ClinicalTrials.gov — NCT06513208

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.