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A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
Logistic Regression Prediction Model vs. Standard of Care for Prediction of Postpartum Hemorrhage - A Pragmatic Randomized Controlled Trial
Who can join
All ages · Women
Full eligibility criteria
Inclusion Criteria: * All vaginal and cesarean deliveries occurring at Vanderbilt University Medical Center Exclusion Criteria: * All patients will be randomized at the time of admission to the obstetric service. Patients who are discharged prior to delivery will be excluded from subsequent analysis. Any patients with a pre-delivery planned hysterectomy (for placenta increta or percreta) will be excluded from the treatment algorithm and primary analysis.
About the study
This research project aims to enhance the safety of childbirth by using advanced computer models to predict the risk of postpartum hemorrhage (PPH).
PPH is a significant concern for mothers during and after delivery. Current risk assessment tools are basic and do not adapt to changing conditions. This study will investigate whether a new and recently validated model for predicting PPH, combined with a provider-facing Best Practice Advisory (BPA) regarding currently recommended strategies triggered by an increased predicted risk, can improve perinatal outcomes.
This study will compare the current category based risk assessment tool with a new, enhanced prediction model which calculates risk based on 21 factors, automatically updates as new information becomes available during labor and, if elevated, provides a provider-facing Best Practice Advisory (BPA) recommending consideration of strategies that are institutionally agreed to represent high-quality practice.
Investigators hypothesize that the enhanced care approach will result in improved perinatal outcomes.
The goal of the study is to improve the wellbeing of mothers during childbirth by harnessing the power of modern technology and data analysis.
What is being tested
- Novel PPH Risk Prediction Model - Comparator Arm B (behavioral)
Sponsor: Holly Ende · Participants: 12,500 · Started: Jan 1, 2025
Contact the study team
- Holly Ende, MD · Phone: 615-322-8476
- Tracie Baker, CCRP · Phone: 615-875-1852
Official record on ClinicalTrials.gov — NCT06513351
Locations in the U.S.
| Tennessee | Vanderbilt University Medical Center, Nashville |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.