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Early Neurovascular Adaptations in Aging Women

Who can join

Ages 18 to 70 · Women · Healthy volunteers welcome

Inclusion Criteria:

* Assigned female at birth (AFAB)
* 18-70 years of age

Exclusion Criteria:

* Assigned male at birth (AMAB)
* Pregnancy, breastfeeding
* Body mass index ≥30 kg/m2
* Taking medications known to affect metabolic, autonomic, and/or respiratory function
* Oral hormonal contraception in last 6 month
* History of hormone replacement therapy
* History of hyster- or oophor-ectomy
* Current smoking/Nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Chronic disease
* Blood pressure ≥140/90 mmHg
* Communication barriers

About the study

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

What is being tested

• Norepinephrine (drug)
• Isoproterenol (drug)
• Acetylcholine (drug)
• Nitroprusside (drug)
• Estrogen (drug)

Sponsor: University of Missouri-Columbia · Participants: 64 · Started: Sep 20, 2024

Contact the study team

• Jacqueline K Limberg · Phone: 573-882-2420

Official record on ClinicalTrials.gov — NCT06520982

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.