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The Aim of This Study is to Determine if Oocyte Sorting for Group Culture Using an Artificial Intelligence Image Analysis Tool (MagentaTM) Increases the Usable Blastocyst Yield and Subsequent Pregnancy in Patients Undergoing IVF

RecruitingObservational studyHealthy volunteers welcome

NiOS (Non-Invasive Oocyte Sorting) Study

Who can join

All ages · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Fresh MII oocytes
* ICSI cycles with patient's or donor's sperm
* Patient's or donor's oocytes
* Full IVF cycle information available (including total number of oocytes retrieved, total MII oocytes, fertilization, embryo and blastocyst development, as well as ploidy status or implantation results, and 6-7 week ultrasound, if applicable)
* Good quality images of MII oocytes taken with a specified camera (Basler) and Future Fertility Software
* Single embryo transfers (SETs) at blastocyst stage.
* Blastocyst freeze-all cycles

Exclusion Criteria:

* Severe male factor infertility (\<1 million motile), including surgically retrieved sperm.
* ICSI cycles inseminating in vitro matured (IVM) oocytes
* Rescue ICSI oocytes (oocytes failed standard IVF and are re-inseminated by ICSI)
* Low quality images - Poor quality images on day of upload or before unblinding
* Lack of correlating reproductive outcomes (full IVF lab results not available).
* Autologous or donor frozen/warmed oocytes
* Day 3 embryo transfers or cleavage stage embryo freezing
* Patients with less than 6 mature oocytes

About the study

The aim of this study is to determine if oocyte sorting for group culture using an artificial intelligence image analysis tool (MagentaTM) increases the usable blastocyst yield and subsequent pregnancy in patients undergoing IVF.

What is being tested

Sponsor: Ovation Fertility · Participants: 450 · Started: Jan 1, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06521372

Locations in the U.S.

NevadaOvation Fertility Las Vegas, Las Vegas
OhioOvation Fertility Cincinnati, Cincinnati
TennesseeOvation Fertility - Nashville, Nashville

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.