Home › NCT06526052
A Randomized Controlled Trial Testing the Effect of the Youth Mindful Awareness Program on Negative Affect (YMAP2).
Targeting Negative Affect Through Mindfulness Training in Youth at Risk for Internalizing Problems (R33)
Who can join
Ages 12 to 17 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Ages 12, 13, 14, 15, 16, 17 * Parental Consent * Participant Assent * Live in Illinois, California, or Tennessee Exclusion Criteria: * current diagnosis of an anxiety or depressive disorder with significant clinical impairment * current alcohol or substance use disorder * current serious suicidal ideation or behavior * lifetime diagnosis of bipolar disorder, schizophrenia, autism, conduct disorder, or developmental delay * reading level below 4th grade * not English speaking at a level that would allow them to participate in the intervention and assessments
About the study
The goal of this randomized clinical trial is to compare the effects of an online mindfulness program to an active supportive comparison condition and a no-intervention control group on reducing and preventing mood and anxiety symptoms in at-risk youth. Youth who are high on trait negative affect will be randomized to one of the three conditions. The primary outcomes of interest are reductions in momentary negative affect and internalizing problems in adolescents ages 12 to 17 years old. All participants will be evaluated prior to being randomized, after the 9-session intervention period, and at a 6-month follow-up.
The first hypothesis is that the mindfulness intervention will predict decreases in stressor-reactive momentary negative affect and internalizing symptoms. The second hypothesis is that changes in momentary negative affect will partially account for the effects of the mindfulness intervention on internalizing symptoms.
What is being tested
- Mindfulness Program (behavioral)
- Active Comparator (behavioral)
Sponsor: Vanderbilt University · Participants: 360 · Started: Apr 1, 2024
Contact the study team
- Judith A Garber, PhD · Phone: 6153305605
- Steven D Hollon, PhD · Phone: 6153305604
Official record on ClinicalTrials.gov — NCT06526052
Locations in the U.S.
| California | University of California, Los Angeles, Los Angeles |
| Illinois | Northwestern University, Evanston |
| Tennessee | Vanderbilt University, Nashville |
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.