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Skin Wetting in Burn Survivors
Who can join
Ages 18 to 65 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: Non-burn survivors * Healthy male and female subjects * 18-65 years of age. * Free of any underlying medical conditions Exclusion Criteria (non-burned individuals): * Any burn-related injuries resulting in at least one night of hospitalization. * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension. * Abnormalities detected on routine screening * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * Body mass index of greater than 30 kg/m\^2. * Pregnant individuals Inclusion Criteria (burn survivors): * Healthy male and female subjects * 18-65 years of age. * Free of any underlying medical conditions * Having a burn injury covering 20-40% or \>40% of the participant's body surface area; at least 50% of those burn injuries must be full thickness that required skin grafting. * Participants must have been hospitalized due to the burn injury for a minimum of 15 days Exclusion Criteria (burn survivors): * Any burn-related injuries resulting in at least one night of hospitalization. * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension. * Abnormalities detected on routine screening * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * Body mass index of greater than 30 kg/m\^2. * Pregnant individuals * Extensive unhealed injured skin
About the study
This project will identify the efficacy of whole body skin wetting aimed to attenuate excessive elevations in internal body temperatures during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects, subjects who experienced burns covering \~20% to 40% of their body surface area, and subject having burns \>40% of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling or whole body skin wetting.
What is being tested
- Whole body cooling (other)
- Non-cooling (other)
Sponsor: University of Texas Southwestern Medical Center · Participants: 40 · Started: Jul 31, 2024
Contact the study team
- Craig Crandall, PhD · Phone: 214-345-4623
- Erin Harper, BS · Phone: 214-345-4737
Official record on ClinicalTrials.gov — NCT06529757
Locations in the U.S.
| Texas | Institute for Exercise and Environmental Medicine, Dallas |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.