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Mechanisms of Improving Fecal Continence Muscles Motor Function

RecruitingHealthy volunteers welcome

Mechanisms of Improving Fecal Continence Muscles Motor Function in Health and Disease

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Healthy volunteers without past or present history of fecal incontinence
* Patients age 18 years and older with reduced anal resting and or squeeze pressure, reflecting weakness of the anal sphincters who can perform the study

Exclusion Criteria:

* Any one less than 18 years old
* Neurological disorders like dementia, cerebrovascular diseases
* Muscle diseases like muscular dystrophy, myopathies
* Inflammatory bowel disease or celiac disease
* Neuro-muscular junction disorders/myasthenia gravis, Eaton-Lambert syndrome
* Organ prolapse, large rectocele(\>2cm), rectal intussusception
* Hip dysplasia or recent hip surgery and immobile patients.
* Patients with complete normal anal resting and squeeze pressure
* Impaired rectal evacuation (dyssynergy defecation)
* Fecal incontinence completely due to loss of rectal sensation
* Subjects unable to contract their external anal sphincter at all

About the study

The investigators hypothesize that different continence muscles have different fatigue characteristics and fatigue induced by resisted contractions will result in significant increase in contractility of the continence muscles and improvement of fecal incontinence severity.

What is being tested

Sponsor: Medical College of Wisconsin · Participants: 340 · Started: Jul 15, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06532123

Locations in the U.S.

WisconsinMedical College of Wisconsin, Milwaukee

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.