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Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

Hematopoiesis in Monoclonal B Cell Lymphocytosis (MBL) and B-Chronic Lymphocytic Leukemia (CLL) Versus Healthy Age-Matched Control Subjects

Who can join

Ages 40 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who

  * Remain untreated
  * Are currently being treated
  * Who have already been treated
* Subjects in the MBL cohort will have a clinically established diagnosis of MBL
* Healthy age-matched control subjects
* Healthy younger control subjects aged \> 40 years

Exclusion Criteria:

* Anyone under 40
* Healthy control subjects must not have a diagnosis of CLL or MBL

About the study

This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.

What is being tested

• Non-Interventional Study (other)

Sponsor: Mayo Clinic · Participants: 50 · Started: Nov 18, 2016

Contact the study team

Official record on ClinicalTrials.gov — NCT06536452

Locations in the U.S.

Conditions

• Chronic Lymphocytic Leukemia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.