Home › Spinal Cord Injuries › NCT06543277
Safety and Feasibility of Paired Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Upper Limb Rehabilitation in Incomplete Spinal Cord Injury
Recruiting
Safety and Feasibility of Paired taVNS With Upper Limb Rehabilitation in Incomplete Spinal Cord Injury
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * diagnosis of traumatic incomplete (AIS B-D) cervical spinal cord injury (C8 and above) * at least 12 months post-traumatic SCI but less than 10 years post-SCI * demonstrate some residual movement in the upper limb (e.g., able to perform pinch movement with thumb and index finger sufficient to grip small objects such as marble) Exclusion Criteria: * non-traumatic SCI * recent ear trauma and skin lesions at the site of stimulation, such as sunburn, cuts, and open sores, * facial or ear pain, * allergic reaction to adhesives and electrodes, * any current or past history of cardiovascular disorders, * intracranial metal implants, pacemakers, * concomitant clinically significant brain injury, * receiving medication that may significantly interfere with the actions of VNS on neurotransmitter systems at study entry * If there is a plan for alteration in upper-extremity therapy or medication for muscle tone during the course of the study; * medical or mental instability; * pregnancy or plans to become pregnant during the study period
About the study
The purpose of this study is to evaluate the safety and feasibility of transcutaneous auricular Vagus Nerve Stimulation (taVNS) paired with upper-limb rehabilitation in adults with tetraplegia caused by cervical spinal cord injury.
What is being tested
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) (device)
Sponsor: The University of Texas Health Science Center, Houston · Participants: 12 · Started: Aug 15, 2025
Contact the study team
- Radha Korupolu, MD · Phone: 713-797-5233
- Shrasti Lohiya · Phone: (713) 797-7132
Official record on ClinicalTrials.gov — NCT06543277
Locations in the U.S.
| Texas | Neurorecovery Research Center, TIRR MHH, Houston The University of Texas Health Science Center at Houston, Houston (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.