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Azithromycin Before Induction

Azithromycin to Prevent Chorioamnionitis in Women Undergoing Induction of Labor, a Randomized Control Trial

Who can join

Ages 18 to 45 · Women · Healthy volunteers welcome

Inclusion Criteria:

* • Third trimester of pregnancy defined as 28 0/7 weeks or more

  * Singleton pregnancy
  * Age 18-45
  * Induction of labor initiated for medical or obstetrical reason or electively over 39 weeks of gestation
  * No contraindication to vaginal delivery
  * Reassuring fetal heart rate tracing
  * Able and willing to provide informed consent

Exclusion Criteria:

* • Does not read or write in English or Spanish

  * Unable or unwilling to give informed consent
  * Use of antibiotic or antiviral agent within the last 7 days
  * Evidence of active infection at the time of initiation of induction (patients with rectovaginal group B streptococcus positive results will be allowed to participate as it is a colonizing organism, unless they show evidence of active infection)
  * Incarcerated Women
  * Active substance abuse
  * Age \< 18

About the study

This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and neonatal infection.

What is being tested

• Azithromycin Pill (drug)
• Placebo (drug)

Sponsor: Arrowhead Regional Medical Center · Participants: 400 · Started: Aug 7, 2023

Contact the study team

• Kristina Nalbandyan, DO · Phone: 8187306222
• Kristina Roloff, DO · Phone: 9514427424

Official record on ClinicalTrials.gov — NCT06543290

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.