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Mobile Health Intervention to Improve Exercise in Pediatric PH

MhOVE-PPH Study: Mobile Health Intervention to Improve Exercise in Pediatric PH

Who can join

Ages 10 to 21 · All sexes

Inclusion Criteria:

* Adolescents between ages 10-21 years.
* Diagnosed with WHO Group 1 PAH or WHO Group 4 PH (CTEPH)
* WHO functional class I-III
* Stable PAH-specific medication regimen for three months prior to enrollment. Subjects with only a single diuretic adjustment in the prior three months will be included. Adjustments in IV prostacyclin for side effect management are allowed.

Exclusion Criteria:

* Prohibited from normal activity due to wheelchair bound status, bed bound status, reliance on a cane/walker, activity-limiting angina, activity-limiting osteoarthritis, or other condition that limits activity.
* Pregnancy
* Diagnosis of PAH etiology other than idiopathic, heritable, or associated.
* Functional class IV heart failure
* Requirement of \> 2 diuretic adjustment in the prior three months.
* Preferred form of activity is not measured by an activity tracker (swimming, yoga, ice skating, stair master, or activities on wheels such as bicycling or rollerblading).
* Involved in any other investigational intervention.

About the study

Children and adults with pulmonary arterial hypertension (PAH) have severely reduced daily activity compared to healthy populations. In adults, investigators recently demonstrated that lower baseline daily step counts associated with increased risk of hospitalization and worsening WHO functional class; similarly, reduced step counts associate with hospitalization in children with PAH. This application builds on our recently completed NIH-funded pilot mobile health (mHealth) trial in adult patients with PAH which demonstrated the ability to remotely increase step counts. The investigators now aim to: (1) adapt our mHealth intervention to the developmental needs and interests of adolescents; and, (2) determine if our intervention increases step counts in adolescents, providing the foundation for a larger trial to assess the impact on quality of life and clinical outcomes.

What is being tested

• mHealth Intervention (device)
• Usual Care (device)

Sponsor: Vanderbilt University Medical Center · Participants: 50 · Started: Dec 1, 2024

Contact the study team

• Natasha Billard · Phone: (434) 851-3306
• Eric Austin, MD · Phone: (615) 343-7617

Official record on ClinicalTrials.gov — NCT06549452

Locations in the U.S.

Conditions

• Pulmonary Arterial Hypertension

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.