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Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars

Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars: An In-vivo Study

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Permanent teeth that are diagnosed with pulp necrosis.
* elected to have a permanent tooth nonsurgical root canal treatment
* Signed informed consent.

Exclusion Criteria:

* Teeth with root fractures or previously root canal treated teeth.
* Teeth with severe loss of structure
* Teeth with vital pulps.

About the study

The purpose of this study is to compare the efficacy of GentleWave versus EdgePro irrigation in the disinfection of infected root canals of human permanent teeth with necrotic pulp.

What is being tested

• GentleWave (device)
• EdgePro laser irrigation (device)
• Irrisafe passive ultrasonic irrigation (device)

Sponsor: The University of Texas Health Science Center, Houston · Participants: 30 · Started: Aug 30, 2024

Contact the study team

• David Jaramillo, DDS · Phone: (713) 486-4224
• Ahmed Shehab-Eldin · Phone: (713) 486-4224

Official record on ClinicalTrials.gov — NCT06554366

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.