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Multifocal HD-tDCS and Motor Function
Personalizing Multifocal Transcranial Direct Stimulation Dose to Target the Motor Network in Older Adults
Who can join
Ages 65 to 85 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Participants should be in good health with normal or corrected-to-normal visual acuity * Right handed * No history of neurological disorder * English speaker * Able to provide written consent prior to admission Exclusion Criteria: * Left-handed * Participants are pregnant, suspect pregnancy or are attempting to become pregnant * Have a pacemaker, intracardiac lines or any other medically implanted device or medicine pump * Have cochlear hearing implants * Taking drugs known to influence neural receptors that facilitate neuroplasticity (see protocol) * Have non removable body piercings or have foreign objects in body * Have metal anywhere in the head that could increase risk of serious injury (not including braces, dental fillings, etc.) (see protocol) * Have a personal or family history of seizure/epilepsy * Taking prescription drugs that lower the threshold for seizures * Recent history of excessive alcohol consumption * History of alcohol addiction/dependence * Recent history of recreational drug use * History of drug addiction/dependence * Recent history of recreational drug use * History of drug addiction/dependence * Diagnosed with a stroke, brain hemorrhage, brain tumor, encephalitis. * Diagnosed with multiple sclerosis * Diagnosed with Parkinson's disease or Alzheimer's disease * Diagnosed with depression in the past 6 months * Diagnosed with attention deficit disorder, schizophrenia, manic depressive (bipolar) disorder * Diagnosed with normal pressure hydrocephalus or increased intra-cranial pressure * Diabetes requiring insulin treatment * Any serious heart disorder or liver disease
About the study
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.
The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
What is being tested
- Standard HD-tDCS intervention (device)
- Multifocal network targeted HD-tDCS intervention (device)
- Functional Magnetic Resonance Imaging (fMRI) (device)
Sponsor: University of Michigan · Participants: 40 · Started: Feb 25, 2025
Contact the study team
- Michael Vesia, PhD · Phone: 734-764-5237
Official record on ClinicalTrials.gov — NCT06561165
Locations in the U.S.
| Michigan | University of Michigan, Ann Arbor |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.