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Optimal Timing for Spontaneous Breathing Trials

Impact of Spontaneous Breathing Trial Timing on Outcomes in Mechanically Ventilated Adult Patients

Who can join

Ages 21 and older · All sexes

Inclusion Criteria:

* Adults aged 21 years or older.
* Patients who have been on mechanical ventilation for more than 48 hours.
* Patients who have completed at least one SBT.

Exclusion Criteria:

* Patients intubated at other hospitals.
* Patients intubated for surgical or interventional procedures.
* Patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO).
* Patients with a tracheostomy.

About the study

This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU. SBTs are tests used to determine if a patient is ready to breathe on their own without the help of a ventilator. The study will compare two different timing strategies for these trials: one group of patients will have the test early in the morning, while the other group will have it later in the morning. By observing the outcomes, such as how long patients need to stay on the ventilator, the study hopes to find the best time to perform these trials to help patients recover more quickly and safely.

What is being tested

• Later Morning Timing of Spontaneous Breathing Trials (other)

Sponsor: Rush University Medical Center · Participants: 348 · Started: Sep 17, 2024

Contact the study team

• JIE LI, PhD · Phone: 3125634643

Official record on ClinicalTrials.gov — NCT06561295

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.