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Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery

Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery: A Randomized Clinical Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* American Society of Anesthesiologists (ASA) I or II.
* At least one tooth will receive EMS.
* Flap design that includes at least one VRI (triangular, rectangular, papilla base or submarginal rectangular).

Exclusion Criteria:

* ASA III or IV.
* Current heavy smokers (\>10 cigarettes/day)
* Uncontrolled diabetes (HbA1c ≥ 7%) or other uncontrolled systemic diseases that may comprise healing, such as vitamin C deficiency, neutrophil deficiencies, immunodeficiency syndromes, or leukemia.
* Surgical access on the palatal surface.
* Acute swelling or abscess present on the day of the surgery.
* Any event or condition that would make continued participation in the study not in the best interest of the subject, as determined by the investigator.
* Pregnancy.
* Development of any medical condition that might affect the treatment and clinical outcomes, as determined by the investigator.
* Initiation of any treatment or exposure that might affect therapy's healing, as determined by the investigator.

About the study

The purpose of this study is to evaluate the effect of Photobiomodulation (PBM) in postoperative pain after endodontic microsurgery (EMS) in patients from the University of Texas Health Science Center at Houston, School of Dentistry Graduate Endodontic Clinic and to assess the soft tissue healing of the vertical releasing incision (VRI) after PBM

What is being tested

• PBM treatment (device)
• PBM sham treatment (device)
• EMS (device)

Sponsor: The University of Texas Health Science Center, Houston · Participants: 90 · Started: Aug 20, 2024

Contact the study team

• Juliana Barros, DDS,MS · Phone: (713) 486-4564

Official record on ClinicalTrials.gov — NCT06574152

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.