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Coping Skills Training for Symptom Management and Daily Steps (Step Up)

Who can join

Ages 18 to 99 · All sexes

Inclusion Criteria:

* receipt of an autologous (auto) HCT or CAR-T cell therapy due to a hematologic malignancy, such as a diagnosis of leukemia, lymphoma, multiple myeloma
* age \>18
* self-reported fatigue, pain, and psychological distress (confirmed at recruitment) - minimum two of three symptoms reported at \>3 on 0-10 scale
* life expectancy \> 12 months

Exclusion Criteria:

* cognitive impairment (e.g., dementia) recorded in the chart or suspected by provider
* metastases to the brain
* presence of a severe psychiatric condition (e.g., psychotic disorder) that would contraindicate safe participation as indicated by the medical chart, treating oncologist, or interactions with the medical/study staff
* inability to converse in English

About the study

The aim of this study is to test the efficacy of a hybrid in-person and mHealth coping skills training and activity coaching intervention (Step Up), to enable HCT patients to effectively cope with symptoms (pain, fatigue, and stress) to improve their ability to engage in physical activity that can improve physical disability.

What is being tested

• Step Up (behavioral)
• Usual Care Plus (UC+) (other)

Sponsor: Duke University · Participants: 177 · Started: Apr 21, 2025

Contact the study team

• Allison Diachina · Phone: 919-416-3421

Official record on ClinicalTrials.gov — NCT06575712

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.