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TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study

TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage (TEAPOT): A Pilot and Feasibility Study

Who can join

Ages 2 to 17 · All sexes

Inclusion Criteria:

1. Received a tonsillectomy
2. Presents to the ED with secondary\* post-tonsillectomy hemorrhage
3. Children between age of 2 to 17 years of age (i.e., before their 18th birthday) \*Secondary post-tonsillectomy hemorrhage is defined as greater than 24 hours from their primary tonsillectomy operation (arrival in recovery/PACU).

Exclusion Criteria:

1. Known and documented bleeding or clotting disorder.
2. Known pregnancy.
3. Patients with known hypersensitivity or allergic response to tranexamic acid.
4. Parents or guardians who cannot communicate in English or Spanish.
5. Intubation prior to enrollment.
6. Previously enrolled patients.

About the study

After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the sore spot. If this mist works well, it could help kids get better by making sure they don't have to go back for more surgery or need blood from someone else. Not having another surgery is good because it means kids won't have to sleep under medicine again, which can sometimes be risky for their brains and breathing, and they won't feel as scared or hurt.

What is being tested

• Tranexamic Acid Injectable Product (drug)
• Normal Saline (other)

Sponsor: The University of Texas Health Science Center at San Antonio · Participants: 12 · Started: Feb 18, 2026

Contact the study team

• Andrew D Meyer, MD, MS · Phone: 210-567-4424
• Stephanie Perez, MHA · Phone: (210) 450-8973

Official record on ClinicalTrials.gov — NCT06580509

Locations in the U.S.

Conditions

• Surgical Blood Loss

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.